CovidV2, Istex, Curation, bibRecord, 000067

Neurovirulence of six different murine coronavirus JHMV variants for rats

Identifieur interne : 000067 ( Istex/Curation ); précédent : 000066; suivant : 000068

Neurovirulence of six different murine coronavirus JHMV variants for rats

Auteurs : Matsubara Yutaka [Japon] ; Watanabe Rihito [Japon] ; Taguchi Fumihiro [Japon]

Source :

Virus Research [ 0168-1702 ] ; 1991.

RBID : ISTEX:69BA27A0D9342A8425702E9CB923C2312A7ED9D3

English descriptors

Teeft :
- Cnsv, Coronavirus, Demyelinating, Demyelinating disease, Demyelinating encephalomyelitis, Determinant, Encephalomyelitis, Fleming, Glial, Glial cells, Infectious virus, Inoculated, Intracerebrally, Intracerebrally inoculated, Jhmv, Jhmv infection, Jhmv variants, Large mrna3, Lesion, Lewis rats, Massa, Meulen, Monoclonal, Monoclonal antibodies, Morbidity, Murine, Murine coronavirus, Nagashima, Neuron, Neurovirulence, Plaque, Previous studies, Rat, Rats inoculated, Sorensen, Spinal, Spinal cord, Stohlman, Taguchi, Variant, Variant viruses, Various titers, Viral, Viral antigen, Viral antigens, Virology, Virus infection, Wege.

Abstract

Abstract: Six variant viruses of the JHMV strain of murine coronavirus with large (cl-2, CNSV, DL and DS) or small (sp-4 and JHM-X) S proteins were compared in terms of their relative neurovirulence in weanling Lewis rats. Inoculation of various doses of the variants revealed that the cl-2 and CNSV were highly virulent and DL and DS were low-virulent, while sp-4 and JHM-X were avirulent. Pathological examination of rats infected with variants cl-2, DL and sp-4 showed that the cl-2 and DL induced severe and mild acute encephalomyelitis, respectively, while no lesions were observed in the central nervous system of rats infected with sp-4. Virus growth and distribution of antigen in rat brains correlated strongly with neurovirulence. These results suggest that S protein plays a role in neurovirulence in rats. In addition, these variant viruses were shown to be useful tools for further analysis of JHMV neurovirulence in animals as well as in cultured cells.

Url:

https://api.istex.fr/ark:/67375/6H6-BP4MTCJ8-B/fulltext.pdf

DOI: 10.1016/0168-1702(91)90060-9

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ISTEX:69BA27A0D9342A8425702E9CB923C2312A7ED9D3

Le document en format XML

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<term>Demyelinating encephalomyelitis</term>
<term>Determinant</term>
<term>Encephalomyelitis</term>
<term>Fleming</term>
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<front><div type="abstract" xml:lang="en">Abstract: Six variant viruses of the JHMV strain of murine coronavirus with large (cl-2, CNSV, DL and DS) or small (sp-4 and JHM-X) S proteins were compared in terms of their relative neurovirulence in weanling Lewis rats. Inoculation of various doses of the variants revealed that the cl-2 and CNSV were highly virulent and DL and DS were low-virulent, while sp-4 and JHM-X were avirulent. Pathological examination of rats infected with variants cl-2, DL and sp-4 showed that the cl-2 and DL induced severe and mild acute encephalomyelitis, respectively, while no lesions were observed in the central nervous system of rats infected with sp-4. Virus growth and distribution of antigen in rat brains correlated strongly with neurovirulence. These results suggest that S protein plays a role in neurovirulence in rats. In addition, these variant viruses were shown to be useful tools for further analysis of JHMV neurovirulence in animals as well as in cultured cells.</div>
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Neurovirulence of six different murine coronavirus JHMV variants for rats

Neurovirulence of six different murine coronavirus JHMV variants for rats

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri